The Amazon is the most popular Ascendancy for the Huntress class in Path of Exile 2, offering a fast-paced, high-damage playstyle centered around critical hits and elemental destruction. At the core of this Ascendancy is Elemental Infusion, a passive that unlocks the potent mechanic known as Infuse Weapon-a key source of AoE and burst damage in endgame builds.

This guide breaks down how Infuse Weapon works, how to unlock it, and how to build around it effectively.

How to Unlock Infuse Weapon in PoE 2

Infuse Weapon is unlocked by selecting the Elemental Infusion node from the Amazon Ascendancy after completing a Trial of the Sekhemas or a Trial of Chaos using the Huntress.

Only 2 Ascendancy Points are needed to access this node.

You can obtain these points by completing the Ascendancy Trial even at its lowest difficulty level.

Once unlocked, Infuse Weapon becomes a passive skill-it cannot be manually activated and instead works in the background when certain requirements are met.

How Infuse Weapon Works

Infuse Weapon operates on an infusion system tied to charge consumption. Here's the breakdown:

Infuse Weapon Activation Flow

Generate a Charge using a skill (e.g., Cull the Weak).

Consume the Charge using a skill (e.g., Lightning Spear).

Infuse Weapon is triggered, granting an Infusion based on the Charge type consumed:

Power Charge → Cold Infusion

Endurance Charge → Fire Infusion

Frenzy Charge → Lightning Infusion

Use a non-melee projectile skill (e.g., Twister) to consume the Infusion and trigger a large AoE blast at the impact location.

Infusion Limits and Cooldown

You can store up to 6 Infusions per element type at once.

Each Infusion lasts 15 seconds before expiring.

You cannot gain new Infusions of a type that has already reached its 6-stack cap.

Best Huntress Skills for Triggering Infuse Weapon

To trigger Infuse Weapon, you need non-melee projectile attacks that consume Charges. These are the best Huntress skills for the job:

Lightning Spear

Explosive Spear

Storm Lance

Glacial Lance

Whirlwind Lance

Each skill unleashes Frenzy or Power Charges and satisfies the projectile requirement to unleash an Infusion explosion.

How to Generate Charges Efficiently

For Infuse Weapon to shine, you must consistently generate Charges. Here's how:

Best Charge Type: Frenzy Charges

The Huntress is naturally geared toward Frenzy Charge generation, which aligns with Lightning Damage and synergizes with Lightning Infusions.

Skill Tree Node: Combat Frenzy

Grants a Frenzy Charge each time you Electrocute, Freeze, or Maim an enemy.

Electrocute is optimal due to its synergy with Lightning builds.

Recommended Gear: Kitoko's Current

These Unique Gloves help inflict Electrocute reliably, enabling faster Frenzy Charge generation.

Alternative Build: Freeze → Cold Infusions

If you prefer a Cold Damage / Freeze Huntress build:

Combine Combat Frenzy with the Resonance node.

This converts Frenzy Charges into Power Charges, fueling Cold Infusions instead.

Summary: Infuse Weapon in Practice

Infuse Weapon transforms the Huntress into a ranged elemental nuke engine, leveraging Charge mechanics to unleash explosive projectiles.

It's a passive effect-you need to meet the triggers: generate → consume → detonate.

Focus on Frenzy Charges and Lightning Skills for the easiest and most powerful synergy.

Always maintain Infusions by rotating through Charge-consuming skills and firing off projectiles to detonate them for massive AoE damage.

If you're playing Amazon Huntress in PoE 2 and haven't built around Infuse Weapon, you're leaving serious elemental firepower on the table. Stack those Charges, let the Infusions flow, and watch enemies melt from your electrified storm of lances and spears. And with access to plenty of PoE 2 currency and PoE 2 items, you've got everything you need to take this build to the next level.