Diablo 4's endgame is where the true challenge begins, with the Boss Ladder offering a path to the game's best gear, including Uniques and Uber Uniques. While these Diablo 4 items can drop from various activities, the chances increase significantly when you focus on endgame bosses from the Boss Ladder. This system, introduced in Season 4 with Patch 1.4.0, involves a progression where each boss is summoned using specific crafting materials, often obtained from defeating the previous boss. The difficulty escalates as you ascend the ladder, with Andariel and Duriel at the pinnacle, offering the highest chances to drop Mythic Uniques.

In this guide, we'll cover when you can start fighting these bosses, where to find them, how to summon them, and what rewards you can expect.

When Can I Start Fighting Bosses in Diablo 4?

You need to reach World Tier 3 to begin accessing bosses on the Boss Ladder. The bosses range in difficulty from level 55 to 100. Once you advance to World Tier 4, you can summon Tormented Bosses, which are much more challenging at level 200 but offer better rewards.

Boss Summoning and Locations

Echo of Varshan (Shadow Damage)

Location: Varshan, introduced in Season 1 (Season of the Malignant), remains the first boss on the ladder.

Summoning Materials:

Malignant Heart (Previously, Varshan's body parts like Gurgling Head, Trembling Hand, and Blackened Femur were required, but these can now be converted into a Malignant Heart at a Herbalist).

Tips: Stack Amethyst Gems and potions for Shadow resistance.

Gregoire, the Galvanic Saint (Lightning Damage)

Location: Hall of the Penitent, south of Ked Bardu in the Dry Steppes.

Summoning Materials:

Living Steel x 2 (World Tier 3)

Living Steel x 5 (World Tier 4)

Tips: Gather Living Steel from Tortured Gifts in the Helltide or from Seasonal mode rewards. Socket Topaz gems for Lightning resistance.

Lord Zir (Shadow Damage)

Location: The Darkened Way, east of Kyovashad in the Fractured Peaks. Only accessible in World Tier 4.

Summoning Materials:

Exquisite Blood x 9 (Drops from Legion events and World Bosses).

Tips: Use Amethyst gems and a Potent Elixir of Shadow Resistance for this fight.

The Beast in the Ice (Cold Damage)

Location: The Glacial Fissure, southwest of Kyovashad in the Fractured Peaks.

Summoning Materials:

Distilled Fear x 9 (Drops from Nightmare Dungeons Tier 30 and above).

Tips: Stack Sapphire gems and consume a Cold Elixir to boost Cold resistance.

Duriel (Poison Damage)

Location: The Gaping Crevasse, east of Gea Kul in Kehjistan.

Summoning Materials:

Mucus Slick Eggs x 2 (From Varshan)

Shards of Agony x 2 (From Grigoire)

Tips: Stack Emeralds and use a Poison Elixir to maximize poison resistance.

Andariel (All Damage Types)

Location: Hanged Man's Hall, east of Tarsarak.

Summoning Materials:

Pincushioned Doll x 2 (From Beast in the Ice)

Sandscorched Shackles x 2 (From Lord Zir)

Tips: Use an 'all resistance' gem-like Diamonds to mitigate the variety of damage types.

Tormented Bosses

Tormented versions of each boss were introduced in Patch 1.4.0, and they drop better rewards but are much more challenging. To summon these, you'll need Stygian Stones, which can be obtained from The Pit of Artificers.

Uber Lilith

While Lilith isn't part of the Boss Ladder, she is considered a Pinnacle Boss, dropping a Resplendent Spark upon her first defeat. She can be found at the Nevesk Church in World Tier 4, and is by far the toughest boss, requiring a perfected build to defeat.

Best Boss to Farm for Mythic Uniques

As of Patch 1.5.0, all Tormented Bosses have a 7.5% chance to drop Mythic Uniques, with each boss offering 5 chances at a 1.5% drop rate. Previously, Andariel and Duriel had the best drop rates, but now all Tormented Bosses have equal chances. Based on ease of battle, Tormented Lord Zir or Tormented Grigoire are recommended for farming, depending on your build.

Conclusion

The Boss Ladder in Diablo 4 offers an escalating challenge that rewards players with some of the best gear in the game. By targeting specific bosses and farming the necessary materials, you can optimize your chances of obtaining Mythic Uniques and other valuable loot. Prepare your build accordingly and ascend the ladder to take on these formidable foes.